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KMID : 0380620090410050552
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 5 p.552 ~ p.559
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Comparison of Anticancer Activities of Ultrasonification Extracts of Callus and Roots from Rhodiola sachalinensis A. Bor
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Ha Ji-Hye
Jeong Hyang-Suk
Jeong Myeong-Hoon
Kim Seung-Seop
Kim Young
Nam Jong-Hyeon
Hwang Baik
Ma Choon-gje
Lee Hyeon-Yong
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Abstract
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In this study, the anticancer activity of the water extract at 100oC was compared to that of the callus extracts via a ultrasonification extraction process. All the extracts were utilized to evaluate cytotoxicity, antioxidant and immune activities. The callus extracted via ultrasonification extraction showed relatively low cytotoxicity on normal human cell lines, HEK293 and HEL299, showing 13.17% and 21.78%, respectively. The callus extract has 59.82% which was similar to 61.70% for water extracts. It was also found that callus extract yielded higher nitric oxide secretion form macrophage than other extracts. The growths of both human stomach adenocarcinoma (AGS) cell and human lung carcinoma (A549) were inhibited up to 70% by adding 1.0 mg/mL of the callus extracts with ultrasonification extraction. This inhibition ratio (70%) was almost close to that of water extract. Human hepatoma carcinoma (HEP3B) cell growth was most significantly inhibited up to 75% by adding 1.0 mg/mL of callus extracts, and its selectivity was highest compared to other extracts. It indicates that the callus extracts could selectively inhibit growth of digestive system-related cancer cells. It can be also concluded from the results of this study that the callus extracts associated with ultrasonification extraction process have the potential for anticancer activity.
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KEYWORD
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Rhodiola sachalinensis A. Bor, callus, ultrasonification extraction, anticancer activity, cytotoxicity
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